MyBioSource.com's GAS41 Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Western Blot. The GAS41 Antibody was generated using GAS41, and YEATS4 as the antigen and it reacts with Human, and Mouse.
Description
Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage.Fischer U., Hum. Mol. Genet. 6:1817-1822(1997).Harborth J., J. Biol. Chem. 275:31979-31985(2000).Ota T., Nat. Genet. 36:40-45(2004)